Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling

doi:10.4251/wjgo.v17.i9.108760

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Sep 15, 2025; 17(9): 108760
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108760

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Figure 6 Uncoupling protein 1 regulates the Rap-1 signaling pathway in gastric cancer cells. A: Volcano plot for differential gene expression; B: The Kyoto Encyclopedia of Genes and Genomes enrichment of the upregulated genes in the low- Uncoupling protein 1 (UCP1)-expression group; C: Western blot for active and total Rap1 in gastric cancer cells with UCP1 knockdown (left) or overexpression (right). UCP1: Uncoupling protein 1; Ctrl: Control; OE: Overexpression.

Citation: Chen YJ, Peng C, Wang LW, Chai JX, Wang JD, He QB. Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling. World J Gastrointest Oncol 2025; 17(9): 108760
URL: https://www.wjgnet.com/1948-5204/full/v17/i9/108760.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i9.108760

Chen YJ, Peng C, Wang LW, Chai JX, Wang JD, He QB. Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling. World J Gastrointest Oncol 2025; 17(9): 108760 [PMID: 40977672 DOI: 10.4251/wjgo.v17.i9.108760]

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