Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling

Figure 5 Uncoupling protein 1 overexpression inhibited tumor growth in vivo. A: In vivo live imaging of mice with a subcutaneously grafted tumor; B: Representative photographs of tumor size in each group; C: Analysis of tumor weight and size in the Uncoupling protein 1 (UCP1)-overexpression and control groups; D: Grafted tumors were subjected to H&E staining. The results indicated that the number of mitotic cells (orange arrow) significantly decreased in UCP1-overexpressed gastric cancer cells compared with control cells (P < 0.001; Image magnification: 400 ×). ^aP < 0.001. Ctrl: Control; OE: Overexpression.