Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling

Table 2 Relationship between uncoupling protein 1 expression and the clinicopathological features of gastric cancer

Characteristics		UCP1 expression		P value	HR (95%CI)
		Negative	Positive
Sex	Male	51	108	0.037a	0.839 (0.702-1.003)
	Female	25	27
Age (years)	≥ 65	42	72	0.787	1.036 (0.802-1.339)
	< 65	34	63
Depth of invasion	T1/T2	10	31	0.084	0.573 (0.298-1.103)
	T3/T4	66	104
Differentiation	Well	9	39	< 0.001b	0.613 (0.451-0.831)
	Moderate	21	48
	Poor	46	48
Lymph mode metastasis	No	18	48	0.074	0.666 (0.419-1.058)
	Yes	58	87
TNM stage	I/II	30	102	< 0.001b	0.522 (0.389-0.701)
	III/IV	46	33

^aP < 0.05.

^bP < 0.01.

χ² test was performed. UCP1: Uncoupling protein 1; OR: Odds ratio; 95%CI: 95% confidence interval.