Fibroblast growth factor 19-fibroblast growth factor receptor 4 axis: From oncogenesis to targeted-immunotherapy in advanced hepatocellular carcinoma

Table 3 Diagnostic performance of serum fibroblast growth factor 19 Levels and other existing markers alone and in combination for differentiation of hepatocellular carcinoma

Cut-off value of FGF19	Biomarker	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC value
FGF19 cut-off value: 200 pg/mL[129]	FGF19 ≥ 200 pg/mL	53.2	95.1	95.9	48.7	0.795
	FGF19 ≥ 200 pg/mL and AFP ≥ 20 ng/mL	76.0	91.5	95.1	64.0
	FGF19 ≥ 200 pg/mL and DCP ≥ 40 mAU/mL	81.3	91.0	95.4	68.8
	FGF19 ≥ 200 pg/mL and AFP ≥ 20 ng/mL, DCP ≥ 40 mAU/mL	87.5	87.2	94.0	76.3
FGF19 cut-off value: 180 pg/mL[130]	FGF19 > 180 pg/mL	100	90	90	100	0.98
FGF19 cut-off value: 140.8 pg/mL[131]	FGF19 ≥ 140.8 pg/mL	81.8	87.9	87.1	82.9
	FGF19 ≥ 140.8 pg/mL and AFP ≥ 13.1 ng/mL	93.9	66.7	75.6	90.9
	FGF19 ≥ 140.8 pg/mL and DCP ≥ 0.725 ng/mL	90.9	45.5	62.5	83.3
	FGF19 ≥ 140.8 pg/mL and AFP ≥ 13.1 ng/mL, DCP ≥ 0.725 ng/mL	93.9	27.3	56.4	81.8

FGF19: Fibroblast growth factor-19; AFP: Alpha-fetoprotein; DCP: Des-γ-carboxy prothrombin; PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the curve.