Fibroblast growth factor 19-fibroblast growth factor receptor 4 axis: From oncogenesis to targeted-immunotherapy in advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Sep 15, 2025; 17(9): 108649
Published online Sep 15, 2025. doi: 10.4251/wjgo.v17.i9.108649

Table 1 Search strategy summary

Items	Specification
Date of search	Jun 5, 2025
Databases and other sources searched	PubMed, EMBASE, Web of Science, Google Scholar and Cochrane Library
Search terms used	Hepatocellular carcinoma, fibroblast growth factor 19, fibroblast growth factor receptor 4, FGFR4 inhibitor, targeted therapy, multi-kinase inhibitor, immunotherapy, immune checkpoint inhibitor, biomarker
Timeframe	1990-2025
Inclusion criteria	(1) Study type: All types; and (2) Language: English
Selection process	The literature was independently screened by two professionals, and any discrepancies were resolved through discussion to achieve consensus

FGFR4: Fibroblast growth factor receptor 4.

Citation: Zhan TA, Xia F, Huang HW, Zhan JC, Liu XK, Cheng Q. Fibroblast growth factor 19-fibroblast growth factor receptor 4 axis: From oncogenesis to targeted-immunotherapy in advanced hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(9): 108649
URL: https://www.wjgnet.com/1948-5204/full/v17/i9/108649.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i9.108649

Zhan TA, Xia F, Huang HW, Zhan JC, Liu XK, Cheng Q. Fibroblast growth factor 19-fibroblast growth factor receptor 4 axis: From oncogenesis to targeted-immunotherapy in advanced hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(9): 108649 [PMID: 40977663 DOI: 10.4251/wjgo.v17.i9.108649]

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