Efficacy of adjuvant chemotherapy in stage II colon cancer patients with twelve or more lymph nodes retrieve

Table 2 Univariate and multivariate analysis of prognostic factors in the Surveillance, Epidemiology, and End Results cohort and the Chinese cohort

Characteristics	Univariate analysis1		Multivariate analysis1		Univariate analysis2		Multivariate analysis2
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
ELN, median (IQR)	0.978 (0.976, 0.980)	< 0.001	0.984 (0.982, 0.986)	< 0.001	0.958 (0.940, 0.976)	< 0.001	0.962 (0.944, 0.979)	< 0.001
Size, median (IQR)	1.005 (1.000, 1.010)	0.03	1.004 (1.000, 1.009)	0.057	0.996 (0.946, 1.048)	0.87
Age
20-64	0.302 (0.286-0.318)	< 0.001	0.333 (0.315-0.351)	< 0.001	0.346 (0.275-0.437)	< 0.001	0.414 (0.326-0.526)	< 0.001
Sex
Male	1.039 (1.002-1.078)	0.039	1.160 (1.118-1.203)	< 0.001	1.196 (0.951-1.505)	0.126
Grade
Grade 3/4	1.214 (1.162-1.268)	< 0.001	1.154 (1.103-1.208)	< 0.001	1.212 (0.886-1.657)	0.23
Histology
Adenocarcinoma
Mucinous adenocarcinoma	1.045 (0.991-1.103)	0.104	1.011 (0.958-1.067)	0.695	1.086 (0.786-1.500)	0.616
Others	1.251 (1.088-1.440)	0.002	1.104 (0.956-1.274)	0.178	0.721 (0.269-1.936)	0.516
T stage
T4	1.568 (1.495-1.644)	< 0.001	1.795 (1.709-1.886)	< 0.001	1.497 (1.192-1.879)	0.001	1.569 (1.249-1.970)	< 0.001
Chemotherapy
Yes	1.885 (1.768-2.009)	< 0.001	1.589 (1.485-1.700)	< 0.001	2.246 (1.775-2.841)	< 0.001	1.865 (1.465-2.375)	< 0.001

¹Surveillance, Epidemiology, and End Results database.

²Chinese registry.

HR: Hazard ratio; CI: Confidence interval; ELN: Examined lymph node; IQR: Interquartile range.