Relationship between uric acid and colon cancer risk: Dose-response analysis and mechanisms

Figure 6 Effects of 740Y-P on the proliferation and migration of HCT-116 cells and the phosphoinositide 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway. A: Effect of phosphoinositide 3-kinases activator 740Y-P on the proliferation of HCT-116 cells; B and C: Effect of 740Y-P on HCT-116 cell migration; D-F: Effect of 740Y-P on phosphoinositide 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway. ^aP < 0.05 vs 0 mg/dL group or between groups; NS: Not statistically significant vs 0 mg/dL group. PI3K: Phosphoinositide 3-kinases; p-PI3K: Phosphorylation-phosphoinositide 3-kinases; AKT: Protein kinase B; p-AKT: Phosphorylation-protein kinase B; mTOR: Mammalian target of rapamycin; p-mTOR: Phosphorylation-mammalian target of rapamycin.