Correlation between sarcopenia diagnosed by C3SMI criteria and prognosis in esophageal cancer patients after radiotherapy

Table 3 Single factors influencing the prognosis of esophageal cancer patients

General data		Good prognosis (n = 71)	Poor prognosis (n = 60)	χ2/t	P value
Age, years	≥ 60	45	27	4.438	0.035
	< 60	26	33
Sex	Male	41	28	1.601	0.206
	Female	30	32
BMI (kg/m2)	≥ 24	38	29	0.350	0.554
	< 24	33	31
Hypertension	Presence	25	25	0.574	0.449
	Absence	46	35
Hyperlipidemia	Presence	31	27	0.024	0.878
	Absence	40	33
CHD	Presence	28	20	0.522	0.470
	Absence	43	40
DM	Presence	23	22	0.263	0.608
	Absence	48	38
Sarcopenia	Presence	38	15	10.981	0.001
	Absence	33	45
Tumor type	Squamous carcinoma	26	23	0.041	0.840
	Adenocarcinoma	45	37
Differentiation degree	Poorly differentiated	22	31	5.774	0.016
	Moderately to well differentiated	49	29
AJCC clinical staging	Stages I-II	28	36	5.503	0.019
	Stage III	43	24
Pathogenic site	Upper esophagus	21	23	1.212	0.546
	Middle esophagus	26	18
	Lower esophagus	24	19
Lymph node metastasis	Presence	25	19	0.183	0.669
	Absence	46	41
Number of lesions		1.84 ± 0.26	1.79 ± 0.23	1.156	0.250
Tumor diameter (cm)	≥ 5	21	18	0.003	0.958
	< 5	50	42
Dissection method	Three-field	25	27	1.302	0.254
	Two-field	46	33
ASA classification	Classes I-II	19	23	1.999	0.157
	Classes III-IV	52	37
HSA (g/L)		42.33 ± 6.99	41.45 ± 8.17	0.664	0.508
PLR		135.69 ± 23.88	135.67 ± 20.45	0.005	0.996
AFP (μg/L)		25.64 ± 2.78	20.33 ± 3.15	10.247	< 0.001
TSP-1 (ng/L)		87.55 ± 9.36	98.64 ± 10.21	6.481	< 0.001
Hb (g/L)		108.64 ± 15.47	112.47 ± 20.65	1.212	0.228
ALB (g/L)		35.77 ± 6.29	34.41 ± 7.62	1.119	0.265
PA (mg/L)		148.64 ± 22.37	145.79 ± 16.88	0.811	0.419
TC (mmol/L)		4.25 ± 0.58	4.24 ± 0.61	0.096	0.924
TG (mmol/L)		1.07 ± 0.16	1.05 ± 0.18	0.673	0.502
KPS score (points)		80.64 ± 9.55	83.86 ± 9.22	1.953	0.053
CEA (μg/L)		5.47 ± 0.62	4.56 ± 0.58	8.620	< 0.001

BMI: Body mass index; AJCC: American Joint Committee on Cancer; CHD: Coronary heart disease; DM: Diabetes mellitus; ASA: American Society of Anesthesiologists; HAS: Human serum albumin; PLR: Platelet to lymphocyte ratio; AFP: Alpha fetal protein; TSP-1: Thrombospondin-1; Hb: Hemoglobin; ALB: Plasma albumin; PA: Prealbumin; CEA: Carcinoembryonic antigen; KPS: Karnofsky performance status; TC: Total cholesterol; TG: Triglyceride.