Correlation between sarcopenia diagnosed by C3SMI criteria and prognosis in esophageal cancer patients after radiotherapy

Table 1 Single factors influencing sarcopenia in esophageal cancer patients

General data		Sarcopenia (n = 53)	Non-sarcopenia (n = 78)	χ2/t	P value
Age, years	≥ 60	36	36	6.042	0.014
	< 60	17	42
Sex	Male	29	40	0.149	0.699
	Female	24	38
BMI (kg/m2)	≥ 24	35	37	4.411	0.036
	< 24	18	41
Hypertension	Presence	20	30	0.007	0.933
	Absence	33	48
Hyperlipidemia	Presence	28	30	2.641	0.104
	Absence	25	48
CHD	Presence	19	29	0.024	0.877
	Absence	34	49
DM	Presence	21	24	1.097	0.295
	Absence	32	54
Tumor type	Squamous carcinoma	24	25	2.360	0.125
	Adenocarcinoma	29	53
Differentiation degree	Poorly differentiated	22	31	0.041	0.840
	Moderately to well differentiated	31	47
AJCC clinical staging	Stages I-II	24	40	0.455	0.500
	Stages III-IV	29	38
Pathogenic site	Upper esophagus	19	25	0.477	0.788
	Middle esophagus	16	28
	Lower esophagus	18	25
Lymph node metastasis	Presence	21	23	1.453	0.228
	Absence	32	55
Number of lesions		1.81 ± 0.23	1.82 ± 0.25	0.232	0.817
Tumor diameter (cm)	≥ 5	20	19	2.701	0.100
	< 5	33	59
Dissection method	Three-field	18	34	1.222	0.269
	Two-field	35	44
ASA classification	Classes I-II	19	23	0.586	0.444
	Classes III-IV	34	55
HSA (g/L)		41.56 ± 5.33	42.18 ± 5.09	0.671	0.503
PLR		136.45 ± 14.27	135.16 ± 14.19	0.509	0.611
AFP (μg/L)		23.44 ± 5.69	23.05 ± 3.47	0.487	0.627
TSP-1 (ng/L)		93.56 ± 14.78	91.99 ± 16.53	0.557	0.579
Hb (g/L)		104.26 ± 32.67	114.56 ± 31.44	1.811	0.072
ALB (g/L)		36.41 ± 8.57	34.29 ± 9.21	1.330	0.186
PA (mg/L)		141.25 ± 16.39	151.47 ± 16.18	3.530	0.001
TC (mmol/L)		4.12 ± 0.87	4.33 ± 0.54	1.704	0.091
TG (mmol/L)		1.05 ± 0.11	1.07 ± 0.18	0.722	0.472
KPS score (points)		78.56 ± 10.56	84.53 ± 8.91	3.490	0.001
CEA (μg/L)		5.01 ± 0.56	5.08 ± 0.62	0.659	0.511

BMI: Body mass index; AJCC: American Joint Committee on Cancer; CHD: Coronary heart disease; DM: Diabetes mellitus; ASA: American Society of Anesthesiologists; HAS: Human serum albumin; PLR: Platelet to lymphocyte ratio; AFP: Alpha fetal protein; TSP-1: Thrombospondin-1; Hb: Hemoglobin; ALB: Plasma albumin; PA: Prealbumin; CEA: Carcinoembryonic antigen; KPS: Karnofsky performance status; TC: Total cholesterol; TG: Triglyceride.