Predictive model for early postoperative stomal complications in colorectal cancer: A systematic review

Table 3 Studies on role of biomarkers which may be useful in early detection of stomal complications

Factors	Findings	Ref.
CRP, PCT	Both CRP and PCT have a NPV in ruling out septic complications. Threshold value for CRP is 170 to 190 on day 3 and 120 mg/dL to 140 mg/dL on day 4	Dai et al[7], Ramanathan et al[18], Giaccaglia et al[21], Kumar et al[22]
NLR	NLR predicts ischemic complications, threshold value being ≥ 3.54 preoperatively and ≥ 5.5 on postoperative day 7	Forget et al[20], Kumar et al[22]
NAR, GLR, GLB	NAR > 0.086, GLR > 3.662, and GLB ≤ 28 g/L are independent predictors of stomal complications	Yuan et al[6]

CRP: C-reactive protein; PCT: Procalcitonin; NPV: Negative predictive value; NLR: Neutrophil-to-lymphocyte ratio; NAR: Neutrophil-to-albumin ratio; GLR: Glucose-to-lymphocyte ratio; GLB: Globulin level.