Role of circulating tumor DNA methylation in gastric cancer initiation and progression: A comprehensive review

doi:10.4251/wjgo.v17.i8.107412

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Aug 15, 2025 (publication date) through Aug 17, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Aug 15, 2025; 17(8): 107412
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.107412

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Figure 1 Liquid biopsy performed by using blood/plasma samples. A: The bloodstream close to the tumor mass receives circulating tumor cells, extracellular vesicles, and free nucleic acids from the tumor; B: The main methods that have been used to analyze circulating free DNA in blood samples are real-time PCR, COLD-PCR, digital PCR, BEAMing, and next-generation sequencing. ctDNA: Circulating free DNA.

Citation: Huang HY, Lan J, Zhuang W. Role of circulating tumor DNA methylation in gastric cancer initiation and progression: A comprehensive review. World J Gastrointest Oncol 2025; 17(8): 107412
URL: https://www.wjgnet.com/1948-5204/full/v17/i8/107412.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i8.107412