Lipid metabolism-related genes in gastric cancer: Exploring oncogenic pathways

doi:10.4251/wjgo.v17.i8.106842

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Aug 15, 2025 (publication date) through Aug 17, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Aug 15, 2025; 17(8): 106842
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.106842

Table 3 Inhibitors of lipogenic enzymes involved in gastric cancer

Inhibitor	Target	Comment	Ref.
Berberine	FABPs	Trigger cell apoptosis by regulating fatty acid metabolism	[57]
Omeprazole	ACLY	Suppress de novo lipogenesis in gastric epithelial cells	[58]
Orlistat	FASN	Increase survival from GC	[59]
A939572	SCD1	Disrupts lipid homeostasis	[60]
Perihexiline	CPT1	Its combination with oxaliptin suppress progression of GIT cancer	[61]
Avasimbe	ACAT1	Target the metabolism of cholesterol of primary gastric tumors	[62]

ACAT1: Acetyl coenzyme A acetyltransferase; ACLY: ATP-citrate lyase; CPT1: Carnitine palmitoyltransferase 1; FABPs: Fatty acid binding proteins; FASN: Fatty acid synthase; GC: Gastric cancer; GIT: Gastrointestinal tract 1; SCD1: Stearoyl-CoA desaturase 1.

Citation: Amir M, Bakht D, Bokhari SFH, Yousaf R, Iqbal A, Nazir H, Waleed M, Naqvi MZ, Tahir M, Dost W. Lipid metabolism-related genes in gastric cancer: Exploring oncogenic pathways. World J Gastrointest Oncol 2025; 17(8): 106842
URL: https://www.wjgnet.com/1948-5204/full/v17/i8/106842.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i8.106842