Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk

doi:10.4251/wjgo.v17.i7.108455

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Jul 15, 2025 (publication date) through Aug 12, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2025; 17(7): 108455
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.108455

Table 2 Sensitive analysis of the causal association between two circulating inflammatory factors and risk of intrahepatic cholangiocarcinoma

Exposure	Outcome	Method	Heterogeneity		Pleiotropy		MR-PRESSO
Exposure	Outcome	Method	Q	P value	Egger intercept	P value	Outliers	P value
Artemin levels	ICC	MRE	12.173	0.878	-0.038	0.303	0	0.325
Artemin levels	ICC	IVW	13.294	0.864			0	0.325
MMP-10 levels	ICC	MRE	3.911	0.996	-0.032	0.265	0	0.695
MMP-10 levels	ICC	IVW	5.260	0.990			0	0.695

ICC: Intrahepatic cholangiocarcinoma; MRE: Mendelian randomization-Egger; MMP: Matrix metalloproteinase; IVW: Inverse-Variance weighted; MR: Mendelian randomization.

Citation: Chen B, Chen J, Chen ZT, Feng ZP, Lv HB, Jiang GP. Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk. World J Gastrointest Oncol 2025; 17(7): 108455
URL: https://www.wjgnet.com/1948-5204/full/v17/i7/108455.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i7.108455