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©The Author(s) 2025.
World J Gastrointest Oncol. Jul 15, 2025; 17(7): 108205
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.108205
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.108205
Table 4 Univariate and multivariate analyses of subgroups associated with grade 4 lymphocytopenia
Characteristics | RT alone | Sequential CRT | Concurrent CRT | |||
Univariate P | Multivariate P | Univariate P | Multivariate P | Univariate P | Multivariate P | |
Gender (male vs female) | 0.952 | 0.097 | 0.092 | |||
Age (≤ 67 years vs > 67 years) | 0.816 | 0.590 | 0.226 | |||
BMI (< 24 vs ≥ 24 kg/m2) | 0.292 | 0.384 | 0.541 | |||
Tumor length (≤ 5 cm vs > 5 cm) | 0.800 | 0.081 | 0.679 | |||
T stage (1+2 vs 3+4) | 0.800 | 0.081 | 0.976 | |||
N stage (0 vs 1 vs 2) | 0.358 | 0.146 | 0.355 | |||
TNM stage (I+II vs III) | 0.099 | 0.212 | 0.050 | |||
RT technique ENI vs IFI | 0.964 | 0.656 | 0.533 | |||
Dosimetric parameters of OARs | ||||||
Heart V5 (≤ 93% vs > 93%) | 0.037 | 0.051 | 0.013 | 0.039 | 0.015 | 0.048 |
Heart V10 (≤ 86% vs > 86%) | 0.058 | 0.037 | 0.001 | 0.509 | 0.026 | 0.033 |
Aorta V5 (≤ 85% vs > 85%) | 0.817 | 0.160 | 0.032 | 0.926 | ||
Aorta V30 (≤ 78% vs > 78%) | 0.380 | 0.384 | 0.195 | |||
Thoracic vertebrae Dmean (≤ 32 Gy vs > 32 Gy) | 0.129 | 0.093 | 0.032 | 0.612 | ||
Thoracic vertebrae V5 (≤ 69% vs > 69%) | 0.380 | 0.401 | 0.018 | 0.485 | ||
Thoracic vertebrae V10 (≤ 67% vs > 67%) | 0.380 | 0.401 | 0.018 | 0.895 | ||
Lung Dmean (≤ 13 Gy vs > 13 Gy) | 0.022 | 0.483 | 0.160 | 0.276 | ||
Lung V5 (≤ 58% vs > 58%) | 0.019 | 0.039 | 0. 016 | 0.045 | 0.013 | 0.043 |
Lung V10 (≤ 42% vs > 42%) | 0.012 | 0.053 | 0.026 | 0.084 | 0.016 | 0.135 |
Lung V20 (≤ 25% vs > 25%) | 0.029 | 0.064 | 0.039 | 0.054 | 0.033 | 0.012 |
- Citation: Li SG, Liu Y, Zhang XY, Li YM, Shen WB, Zhu SC. Effects of radiotherapy on lymphocytes in patients with middle and lower esophageal cancer and its relationship with prognosis. World J Gastrointest Oncol 2025; 17(7): 108205
- URL: https://www.wjgnet.com/1948-5204/full/v17/i7/108205.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v17.i7.108205