Retrospective Study
Copyright ©The Author(s) 2025.
World J Gastrointest Oncol. Jul 15, 2025; 17(7): 108205
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.108205
Table 4 Univariate and multivariate analyses of subgroups associated with grade 4 lymphocytopenia
Characteristics
RT alone
Sequential CRT
Concurrent CRT
Univariate P
Multivariate P
Univariate P
Multivariate P
Univariate P
Multivariate P
Gender (male vs female) 0.9520.0970.092
Age (≤ 67 years vs > 67 years) 0.8160.5900.226
BMI (< 24 vs ≥ 24 kg/m2) 0.2920.3840.541
Tumor length (≤ 5 cm vs > 5 cm) 0.8000.0810.679
T stage (1+2 vs 3+4) 0.8000.0810.976
N stage (0 vs 1 vs 2) 0.3580.1460.355
TNM stage (I+II vs III) 0.0990.2120.050
RT technique ENI vs IFI0.9640.6560.533
Dosimetric parameters of OARs
Heart V5 (≤ 93% vs > 93%) 0.0370.0510.0130.0390.0150.048
Heart V10 (≤ 86% vs > 86%) 0.0580.0370.0010.5090.0260.033
Aorta V5 (≤ 85% vs > 85%) 0.8170.1600.0320.926
Aorta V30 (≤ 78% vs > 78%) 0.3800.3840.195
Thoracic vertebrae Dmean (≤ 32 Gy vs > 32 Gy) 0.1290.0930.0320.612
Thoracic vertebrae V5 (≤ 69% vs > 69%) 0.3800.4010.0180.485
Thoracic vertebrae V10 (≤ 67% vs > 67%) 0.3800.4010.0180.895
Lung Dmean (≤ 13 Gy vs > 13 Gy) 0.0220.4830.1600.276
Lung V5 (≤ 58% vs > 58%) 0.0190.0390. 0160.0450.0130.043
Lung V10 (≤ 42% vs > 42%) 0.0120.0530.0260.0840.0160.135
Lung V20 (≤ 25% vs > 25%) 0.0290.0640.0390.0540.0330.012