Effects of radiotherapy on lymphocytes in patients with middle and lower esophageal cancer and its relationship with prognosis

Table 3 Univariate and multivariate analyses of variables associated with grade 4 lymphocytopenia

Characteristics	Univariate		Multivariate
	OR	P value	OR	P value
Gender (male vs female)	3.182	0.048	4.928	0.045
Age (≤ 67 years vs > 67 years)	0.451	0.067
BMI (< 24 vs ≥ 24 kg/m2)	0.746	0.502
Tumor length (≤ 5 cm vs > 5 cm)	1.322	0.510
T stage (1+2 vs 3+4)	1.322	0.510
N stage (0 vs 1 vs 2)	2.549	0.011	0.683	0.176
TNM stage (I+II vs III)	3.612	0.003	6.754	0.003
Treatment regimen RT alone vs SCRT vs CCRT	1.351	0.219
RT technique ENI vs IFI	0.655	0.322
Dosimetric parameters of OARs
Heart V5 (≤ 93% vs > 93%)	3.458	0.006	0.518	0.228
Heart V10 (≤ 86% vs > 86%)	3.833	0.003	12.808	0.046
Aorta V5 (≤ 85% vs > 85%)	2.829	0.019	1.054	0.955
Aorta V30 (≤ 78% vs > 78%)	2.374	0.044	1.288	0.713
Thoracic vertebrae Dmean (≤ 32 Gy vs > 32 Gy)	4.259	0.001	0.470	0.339
Thoracic vertebrae V5 (≤ 69% vs > 69%)	3.300	0.007	0.803	0.822
Thoracic vertebrae V10 (≤ 67% vs > 67%)	3.133	0.010	1.938	0.462
Lung Dmean (≤ 13 Gy vs >13 Gy)	2.719	0.022	0.873	0.092
Lung V5 (≤ 58% vs > 58%)	3.300	0.007	5.324	0.048
Lung V10 (≤ 42% vs > 42%)	3.640	0.004	0.646	0.187
Lung V20 (≤ 25% vs > 25%)	2.864	0.016	7.631	0.031

BMI: Body mass index; RT: Radiotherapy; SCRT: Sequential chemoradiotherapy; CCRT: Concurrent chemoradiotherapy; ENI: Elective nodal irradiation; IFI: Involved-field irradiation; OARs: Organs at risk.