Comparison of prognostic factors and their differences in intrahepatic, hilar, and distal cholangiocarcinoma: A systematic review and meta-analysis

Table 2 Pooled results of all available studies in measured outcomes

Measured outcomes	No. studies	No. patients		Model (fixed/random)	OR/HR	95%CI	P (overall test)	Heterogeneity		Begg test	Egger test
								I2	P value	Pr >|z1	P >|t|1
Overall survival	9	IHCC: 6296	PHCC: 6716	Random	HR = 1.02	0.83-1.24	P = 0.88	58%	0.01	1	0.137
Node metastasis	6	IHCC: 651	PHCC: 817	Fixed	OR = 0.69	0.55-0.88	P = 0.003	0%	0.85	0.469	0.492
Neural invasion	3	IHCC: 435	PHCC: 382	Random	OR = 0.71	0.11-4.64	P = 0.72	96%	< 0.00001	1	0.671
Vascular invasion	3	IHCC: 453	PHCC: 384	Random	OR = 0.82	0.28-2.38	P = 0.72	90%	< 0.0001	1	0.657
Overall survival	8	IHCC: 6227	DCC: 1153	Random	HR = 1.07	0.18-1.36	P = 0.59	56%	0.03	0.533	0.355
Node metastasis	5	IHCC: 522	DCC: 445	Fixed	OR = 0.33	0.23-0.45	P = 0.00001	70%	0.009	0.816	0.631
Neural invasion	-	-	-	-	-	-	-	-	-	-	-
Vascular invasion	3	IHCC: 661	DCC: 250	Fixed	OR = 1.66	1.22-2.28	P = 0.001	91%	< 0.0001	0.333	0.263
Overall survival	10	PHCC: 6833	DCC: 1330	Random	HR = 1.06	0.92-1.22	P = 0.42	41%	0.09	1	0.352
Node metastasis	7	PHCC: 989	DCC: 622	Random	OR = 0.48	0.29-0.81	P = 0.005	80%	< 0.0001	0.381	0.952
Neural invasion	3	PHCC: 573	DCC: 250	Random	OR = 2.35	0.76-7.28	P = 0.14	90%	< 0.0001	0.333	0.065
Vascular invasion	-	-	-	-	-	-	-	-	-	-	-

¹P value for statistical tests (e.g., Begg and Egger tests).

IHCC: Intrahepatic cholangiocarcinoma; PHCC: Peri-hilar cholangiocarcinoma; DCC: Distal cholangiocarcinoma.