SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma

Figure 8 Molecular mechanism by which SAC3 domain containing 1 promotes the progression of hepatocellular carcinoma. In hepatocellular carcinoma cells, the upregulated expression of SAC3 domain containing 1 enhances the expression of glycolysis-related genes by regulating the β-Catenin/c-Myc signaling axis, thereby increasing the cellular glycolytic capacity and adenosine triphosphate production rate to meet the demands of large-scale biosynthesis and proliferation in cancer cells, ultimately promoting the progression of hepatocellular carcinoma. SAC3D1: SAC3 domain containing 1; TCF: T-cell factor; GLUT1: Glucose transporter 1; HK2: Hexokinase 2; PKM2: Pyruvate kinase M2; LDHA: Lactate dehydrogenase A.