SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma

Figure 3 SAC3 domain containing 1 promotes metastasis of hepatocellular carcinoma cells in vitro and in vivo. ^aP < 0.05, ^cP < 0.001. A: Gene set enrichment analysis was conducted to explore the signaling pathways affected by the upregulation of SAC3 domain containing 1 (SAC3D1) expression; B: The wound healing assay was utilized to validate the effect of SAC3D1 overexpression on hepatocellular carcinoma cell migration, bar = 200 μm; C: Western blotting results demonstrate that the expression level of SAC3D1 modulates the expression of migration-related proteins in hepatocellular carcinoma cells; D: Metastatic tumor nodules in lungs of two groups of nude mice; E: The numbers of metastatic tumor nodules per field of view in lungs of two groups; F: The metastatic tumor nodules in lungs of nude mice by hematoxylin and eosin staining, bar = 50 μm. SAC3D1: SAC3 domain containing 1; SNAI1: Snail family transcriptional repressor 1.