Predictive value of neutrophil-to-lymphocyte ratio combined with carcinoembryonic antigen in postoperative adjuvant chemotherapy after gastric cancer surgery

Table 2 Cox single factor regression analysis

Variables	HR (95%CI)	P value
Gender: Male vs female	1.05 (0.84, 1.31)	0.668
Old	1.02 (1.01, 1.03)	< 0.001
Smoke: No smoking vs long term smoking	1.0006 (0.8662, 1.1559)	0.994
Drink: No drinking vs long term drinking	0.92 (0.76, 1.13)	0.438
Glycuresis: Glycuresis vs No Glycuresis	0.95 (0.72, 1.27)	0.736
Hypertension: Hypertension vs No Hypertension	0.96 (0.8, 1.15)	0.65
Diseases: Cardiovascular and cerebrovascular diseases vs no diseases	0.95 (0.72, 1.27)	0.748
Location: Ref		0.408
Proximal
Middle	1.01 (0.83, 1.23)	0.913
Distal	0.89 (0.75, 1.07)	0.214
Lauren: Ref		< 0.001
Intestinal
Diffuse	1.84 (1.43, 2.36)	< 0.001
Mixed	1.57 (1.22, 2.03)	< 0.001
Histological grade: Ref
Moderately		< 0.001
Moderately to highly	1.71 (1.38, 2.12)	< 0.001
Highly	1.9 (1.55, 2.31)	< 0.001
AJCC stage: Ref
I		< 0.001
II	2.41 (1.65, 3.5)	< 0.001
III	7.35 (5.27, 10.27)	< 0.001
IV	12.07 (7.69, 18.96)	< 0.001
Invasion depth T: Ref		< 0.001
I
II	1.85 (1.11, 3.1)	0.019
III	4.88 (3.31, 7.19)	< 0.001
IV	7 (4.8, 10.21)	< 0.001
Vascular invasion: Invasion vs no invasion	3.03 (2.59, 3.54)	< 0.001
Perineural invasion: Invasion vs no invasion	2.5 (2.15, 2.91)	< 0.001
Surgical type: Ref
Laparoscope surgery		< 0.001
Traditional surgery	1.21 (1.03, 1.42)	0.018
Non radical surgery	8.1 (5.76, 11.38)	< 0.001
Postoperative chemotherapy: Chemotherapy vs no chemotherapy	1.13 (0.98, 1.3)	0.103
CEA	1.01 (1.01, 1.01)	< 0.001
CA199	1.0029 (1.0022, 1.0036)	< 0.001
CA50	1.0021 (1.0015, 1.0026)	< 0.001
CA724	1.0075 (1.006, 1.009)	< 0.001
CA242	1.0034 (1.0025, 1.0044)	< 0.001
TPS	1.001 (1.0006, 1.0014)	< 0.001
AFP	1 (1, 1.0001)	0.001
NLR	1.1 (1.06, 1.13)	< 0.001
PLR	1.003 (1.0022, 1.0038)	< 0.001

NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; TPS: Tissue polypeptide specific antigen; AFP: Alpha-fetoprotein.