Predictive value of neutrophil-to-lymphocyte ratio combined with carcinoembryonic antigen in postoperative adjuvant chemotherapy after gastric cancer surgery

Table 1 Baseline data table for research variables grouped by chemotherapy, n (%)

Variables	Total (n = 1512)	No chemotherapy (n = 841)	Chemotherapy (n = 671)	P value
Gender				0.279
Female	282 (18.7)	165 (19.6)	117 (17.4)
Male	1230 (81.3)	676 (80.4)	554 (82.6)
Old, mean ± SD	59.8 ± 9.9	61.6 ± 9.8	57.5 ± 9.4	< 0.001
Smoke				0.459
No smoking	816 (54.0)	461 (54.8)	355 (52.9)
Long term smoking	696 (46.0)	380 (45.2)	316 (47.1)
Drink				0.421
No drinking	1268 (83.9)	711 (84.5)	557 (83)
Long term drinking	244 (16.1)	130 (15.5)	114 (17)
Glycuresis				0.349
No glycuresis	1407 (93.1)	778 (92.5)	629 (93.7)
Glycuresis	105 (6.9)	63 (7.5)	42 (6.3)
Hypertension				0.206
No hypertension	1199 (79.3)	657 (78.1)	542 (80.8)
Hypertension	313 (20.7)	184 (21.9)	129 (19.2)
Diseases				0.828
No diseases	1397 (92.8)	774 (92.7)	623 (93)
Cardiovascular and cerebrovascular diseases	108 (7.2)	61 (7.3)	47 (7)
Location				0.263
Proximal	826 (55.5)	444 (53.8)	382 (57.7)
Middle	282 (19.0)	159 (19.2)	123 (18.6)
Distal	380 (25.5)	223 (27)	157 (23.7)
Lauren				0.148
Intestinal	252 (32.1)	139 (34.9)	113 (29.2)
Diffuse	258 (32.9)	120 (30.2)	138 (35.7)
Mixed	275 (35.0)	139 (34.9)	136 (35.1)
Histological grade				0.005
Moderately	384 (28.6)	232 (32.2)	152 (24.4)
Moderately to highly	385 (28.6)	200 (27.8)	185 (29.6)
Highly	574 (42.7)	287 (39.9)	287 (46)
AJCC stage				< 0.001
I	259 (18.4)	230 (30.4)	29 (4.4)
II	325 (23.0)	161 (21.3)	164 (25)
III	778 (55.1)	347 (45.9)	431 (65.8)
IV	48 (3.4)	17 (2.2)	31 (4.7)
Invasion depth T				< 0.001
I	212 (15.0)	188 (24.7)	24 (3.7)
II	120 (8.5)	82 (10.8)	38 (5.8)
III	424 (30.0)	200 (26.3)	224 (34.3)
IV	658 (46.5)	290 (38.2)	368 (56.3)
Vascular invasion				< 0.001
No invasion	772 (54.2)	488 (63.2)	284 (43.5)
Invasion	653 (45.8)	284 (36.8)	369 (56.5)
Perineural invasion				< 0.001
No invasion	827 (58.0)	502 (65)	325 (49.7)
Invasion	599 (42.0)	270 (35)	329 (50.3)
Surgical type				< 0.001
Laparoscope surgery	532 (35.2)	343 (40.8)	189 (28.2)
Traditional surgery	937 (62.1)	464 (55.2)	473 (70.6)
Non radical surgery	41 (2.7)	33 (3.9)	8 (1.2)
Neutrophils, mean ± SD	3.9 ± 1.7	3.9 ± 1.7	4.0 ± 1.7	0.207
NLR	2.3 ± 1.6	2.3 ± 1.6	2.3 ± 1.5	0.651
PLR	153.2 ± 73.8	148.7 ± 71.8	158.8 ± 75.8	0.008
CEA	6.7 ± 17.9	5.7 ± 16.0	8.0 ± 19.9	0.017
CA199	41.3 ± 88.2	38.2 ± 88.1	45.0 ± 88.1	0.154
CA50	24.9 ± 109.2	28.3 ± 129.0	21.1 ± 82.1	0.284
CA724	13.9 ± 36.7	13.7 ± 37.1	14.1 ± 36.2	0.808
CA242	24.3 ± 63.0	20.7 ± 57.7	28.4 ± 68.5	0.025
TPS	126.3 ± 153.7	127.7 ± 145.9	124.8 ± 162.2	0.762
AFP	90.5 ± 1774.9	14.8 ± 163.4	178.4 ± 2602.0	0.09
State				0.011
Survival	770 (50.9)	453 (53.9)	317 (47.2)
Death	742 (49.1)	388 (46.1)	354 (52.8)

NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; TPS: Tissue polypeptide specific antigen; AFP: Alpha-fetoprotein.