Adult pancreatoblastoma: Systematic review of the literature and case report of a young adult patient

Table 4 Tumor histological features

Histological features	Ref.
Acinar cell groups/differentiation	Case from this study[6,9-11,13,14,28-31,37,40,49,52]
AE1/AE3 (cytokeratin)	[7,10,13,29,31,42,50]
A-hematoxylin	[50]
Alpha-1-antitrypsin	[30]
Alpha-1-chymotrypsin	[30]
Basophilic cells	[37]
Bland nuclei cells	[6]
Blast-like cells	[7]
Board sheets of cells separated by fibrous bands	Case from this study[29]
Chromogranin	Case from this study[6,7,9,28-30,41,52,53]
Chymotrypsin	[4,7,9,17,26,28,29,41]
Cyclin-D1	[28]
EMA squamoid corpuscles	[28]
Eosinophilic cytoplasmic granules/cells	[6,29,30,50]
Epithelioid	[11,13,30,40]
Fibrous bands	Case from this study[6,8,28]
Fine chromatin	[28]
Granular appearance	[41,50]
Grooved nuclei	[7,28]
High nuclear to cytoplasmic ratio	[42,50]
INSM1	[28,52]
Ki-67 > 40%	[8,28,31,38,50]
Focal nuclear molding	[7]
Nested/trabecular growth	[28,30,39,52]
Neuroendocrine component/differentiation	[28,37,52]
NSE	[30,31,38]
Pancytokeratin	[39,54]
Papilae with rare stromal fragments	[42]
Polarization and granular cytoplasm	[30]
Polygonal/spindled cells	[30]
Prominent nucleoli	[8,42]
Pseudopapillae	[7]
Rosette-like formations	Case from this study[52,54]
Squamous corpuscles/nests/differentiation/clusters/morules	[9-13,28,29,39-41,49,50,52,53]
Synaptophysin	Case from this study[9-11,27-30,38,41,43,52]
Trypsin	[4,6,7,9,17,26,28,29,41,52]
Undifferentiated small cells	Case from this study[11]

AE1: Anti-epithelial antigen 1; AE3: Anti-epithelial antigen 3; INSM1: Insulinoma-associated protein 1; NSE: Neuron-specific enolase.