Prognostic value of immune-inflammation and nutritional indices in advanced hepatocellular carcinoma patients receiving immunotherapy with compound Kushen injection

Table 4 Univariate and multivariate analysis of the clinicopathological characteristics

Independent factor	OS		PFS
	HR (95%CI)	P value	HR (95%CI)	P value
Univariate analysis
Age	1.108 (0.635-1.934)	0.718	1.296 (0.732-2.296)	0.374
Sex	1.03 (0.572-1.857)	0.921	1.263 (0.691-2.309)	0.443
Albumin	0.907 (0.832-0.988)	0.028	0.913 (0.849-0.982)	0.015
WBC	0.999 (0.956-1.044)	0.959	1.008 (0.973-1.044)	0.685
Neutrophil	1.194 (1.062-1.343)	0.008	1.107 (0.991-1.236)	0.102
Lymphocyte	1.064 (0.559-2.023)	0.851	0.765 (0.404-1.447)	0.407
Monocyte	0.759 (0.349-1.649)	0.460	0.653 (0.313-1.365)	0.205
AFP	0.97 (0.517-1.850)	0.948	0.907 (0.474-1.738)	0.768
HBV	1.83 (0.898-3.730)	0.116	0.865 (0.425-1.761)	0.686
Child-Pugh grade	1.629 (0.836-3.176)	0.169	1.688 (0.866-3.289)	0.141
Tumor size	1.096 (0.623-1.928)	0.750	1.096 (0.623-1.928)	0.750
ECOG performance status	1.505 (0.628-3.607)	0.382	0.535 (0.207-1.336)	0.142
SII	1.004 (1.000-1.007)	0.031	1.005 (1.002-1.008)	0.002
PNI	0.944 (0.882-1.012)	0.105	0.927 (0.871-0.987)	0.016
AS	3.175 (1.182-8.530)	0.042	20.308 (3.783-109.043)	0.000
Multivariate analysis
Albumin	0.895 (0.804-0.995)	0.041	0.962 (0.833-1.111)	0.597
AS	1.21 (11.4-0.986)	0.053	2.764 (1.967-2.602)	0.003
PNI	1.002 (0.998-1.006)	0.403	1.003 (0.999-1.007)	0.131
SII	1.043 (0.920-1.181)	0.512	1.000 (0.881-1.134)	0.999
SII-PNI	2.357 (1.458-2.433)	0.000	0.626 (6.572-0.532)	0.197

OS: Over survival; PFS: Progression-free survival; HR: Hazard ratio; WBC: White blood cell; AFP: Alpha fetoprotein; HBV: Hepatitis B virus; CI: Confidence interval; AS: Ascites; SII: Systemic immune-inflammation index; PNI: Prognostic nutritional index.