Neutrophil extracellular traps predict sensitivity to neoadjuvant chemotherapy combined with immunotherapy in locally advanced gastric cancer

doi:10.4251/wjgo.v17.i7.105723

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2025; 17(7): 105723
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.105723

Table 2 Pre-neoadjuvant chemotherapy combined with immunotherapy neutrophil extracellular traps density correlates with treatment response in locally advanced gastric cancer patients receiving neoadjuvant chemotherapy combined with immunotherapy, n (%)

Characteristics	High NETs (n = 16)	Low NETs (n = 15)	P value
pCR			0.037
no-pCR	15 (94)	9 (60)
pCR	1 (6)	6 (40)
Respond			0.023
No	14 (88)	7 (47)
Yes	2 (12)	8 (53)

NET: Neutrophil extracellular traps; pCR: Pathological complete response.

Citation: Lv Y, Li WX, Sun L, Xin LP, Li T, Zhong WT, Zhu HY, An R, Liu AJ, Chen L. Neutrophil extracellular traps predict sensitivity to neoadjuvant chemotherapy combined with immunotherapy in locally advanced gastric cancer. World J Gastrointest Oncol 2025; 17(7): 105723
URL: https://www.wjgnet.com/1948-5204/full/v17/i7/105723.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i7.105723