Predictive value of a nomogram model for treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Table 2 Comparison of inflammatory and tumor markers between good and poor response groups following neoadjuvant chemoradiotherapy, mean ± SD

Variable	Good response group (n = 36)	Poor response group (n = 142)	t value	P value
CRP (mg/L)	9.0 ± 1.4	13.3 ± 2.8	8.922	< 0.001
IL-6 (ng/L)	12.5 ± 3.2	18.7 ± 3.6	9.428	< 0.001
TNF-α (ng/L)	37.0 ± 8.6	41.9 ± 9.1	2.917	0.004
CEA (μg/L)	5.7 ± 1.1	8.1 ± 1.3	10.19	< 0.001
CA19-9 (U/mL)	46.1 ± 9.0	50.1 ± 10.1	2.167	0.032
NLR	4.5 ± 0.7	4.7 ± 0.8	1.372	0.172
PLR	346.8 ± 55.9	357.1 ± 59.7	0.936	0.351

CRP: C-reactive protein; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9.