Flap endonuclease-1 promotes pancreatic cancer progression via AKT/mTOR signaling pathway

Figure 7 mTOR pathway activation rescues the suppressive effects of flap endonuclease-1 knockdown on pancreatic cancer cell proliferation and migration. A and B: Colony formation assays evaluating the proliferative capacity of flap endonuclease-1 (FEN1)-knockdown PATU8988T and PANC-1 cells following treatment with the AKT activator SC79; C and D: Transwell migration assays assessing the migratory potential of FEN1-knockdown PATU8988T and PANC-1 cells treated with SC79. Representative images and quantitative analysis of migrated cells are shown (data represent mean ± SD from three independent experiments). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.