Flap endonuclease-1 promotes pancreatic cancer progression via AKT/mTOR signaling pathway

Figure 1 Elevated flap endonuclease-1 expression in pancreatic cancer correlates with poor prognosis. A: Analysis of flap endonuclease-1 (FEN1) mRNA expression in pancreatic cancer (PC) tissues derived from The Cancer Genome Atlas and Genotype-Tissue Expression databases; B: Box plots depicting FEN1 expression across six independent PC microarray datasets; C: Correlation analysis between FEN1 expression levels and overall survival and disease-free survival in PC patients, based on Gene Expression Profiling Interactive Analysis database; D: Western blot analysis of FEN1 protein expression in human pancreatic cell line cells and five PC cell lines; E: Comparative analysis of FEN1 protein expression in eight paired PC tissues and adjacent non-tumor tissues; F: Analysis of FEN1 expression patterns across PC cell lines from the Cancer Cell Line Encyclopedia database. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.