Noninvasive prediction of Ki-67 expression in pancreatic cancer via contrast-enhanced ultrasound quantitative parameters: A diagnostic model study

Table 7 Analysis of the receiver operating characteristic curve for differentiating high expression of the Ki-67

	AUC (95%CI)	P value	Diagnostic threshold	Specificity	Sensitive	Youden
Rs50	0.801 (0.682-0.919)	0.000b	7.105	0.586	1	0.586
IMAX	0.859 (0.754-0.964)	0.000b	53.825	0.724	0.96	0.684
RT	0.303 (0.155-0.452)	0.013b	7.31	0.103	0.96	0.063
WinAUC	0.617 (0.465-0.768)	0.143	1034.04	0.897	0.36	0.257
FHT	0.430 (0.276-0.584)	0.376	236.155	1	0.04	0.04
WoutAUC	0.721 (0.584-0.859)	0.005b	29092.74	0.793	0.64	0.443
WioAUC	0.721 (0.584-0.859)	0.005b	29327.415	0.793	0.64	0.433
WoutR	0.818 (0.706-0.930)	0.000b	283.9	0.655	0.92	0.575
FT	0.421 (0.268-0.574)	0.319	67.805	0.414	0.6	0.014
Rs1090	0.863 (0.759-0.968)	0.000b	6.958	0.759	0.92	0.679
WinR	0.620 (0.497-0.773)	0.131	72.18	0.897	0.36	0.257
Fs50	0.162 (0.051-0.274)	0.000b	0.82	1	0	0
AUC	0.727 (0.591-0.863)	0.004b	37672.645	0.759	0.65	0.399
TTP	0.343 (0.188-0.498)	0.048a	8.84	0.241	0.88	0.121
mTT	0.491 (0.334-0.648)	0.910	66.745	0.483	0.64	0.123
Size	0.682 (0.536-0.828)	0.022a	3.45	0.552	0.84	0.392

^aP < 0.05.

^bP < 0.01.

CI: Confidence interval; Rs50: Rise slope 50%; IMAX: Maximum intensity; RT: Rise time; WinAUC: Wash-in area under the curve; FHT: Falling half time; WoutAUC: Wash-out area under the curve; WioAUC: Wash-in and out area under curve; FT: Falling time; Rs1090: Rise slope 10%-90%; WinR: Wash-in rate; Fs50: Falling slope 50%; AUC: Area under the curve; TTP: Time to peak; mTT: Mean transit time; WoutR: Wash-out rate.