Noninvasive prediction of Ki-67 expression in pancreatic cancer via contrast-enhanced ultrasound quantitative parameters: A diagnostic model study

doi:10.4251/wjgo.v17.i6.107919

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Jun 15, 2025; 17(6): 107919
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.107919

Table 6 Analysis of the receiver operating characteristic curve for differentiating low expression of the Ki-67

	AUC (95%CI)	P value	Diagnostic threshold	Specificity	Sensitive	Youden
Rs50	0.199 (0.081-0.318)	0.000^b	28.09	1	0.034	0.034
IMAX	0.141 (0.036-0.246)	0.000^b	17.93	0	1	0
RT	0.697 (0.548-0.845)	0.013^b	13.305	0.92	0.586	0.506
WinAUC	0.383 (0.232-0.535)	0.143	247.535	0.36	0.655	0.015
FHT	0.570 (0.416-0.724)	0.376	44.05	0.92	0.241	0.161
WoutAUC	0.279 (0.141-0.416)	0.005^b	122023.5	1	0	0
WioAUC	0.279 (0.141-0.416)	0.005^b	128423.37	1	0	0
WoutR	0.380 (0.141-0.294)	0.000^b	1233.34	1	0	0
FT	0.579 (0.426-0.732)	0.319	90.095	0.84	0.345	0.185
Rs1090	0.137 (0.032-0.241)	0.000^b	23.195	1	0.034	0.034
WinR	0.380 (0.227-0.533)	0.131	75.55	0	1	0
Fs50	0.838 (0.726-0.949)	0.000^b	-0.695	0.88	0.759	0.639
AUC	0.273 (0.137-0.409)	0.004^b	164597.03	1	0	0
TTP	0.657 (0.502-0.812)	0.048^a	14.33	0.92	0.586	0.506
mTT	0.509 (0.352-0.666)	0.910	128.52	1	0.138	0.138
Size	0.138 (0.172-0.464)	0.022^a	0.70	1	0	0

^aP < 0.05.

^bP < 0.01.

CI: Confidence interval; Rs50: Rise slope 50%; IMAX: Maximum intensity; RT: Rise time; WinAUC: Wash-in area under the curve; FHT: Falling half time; WoutAUC: Wash-out area under the curve; WioAUC: Wash-in and out area under curve; FT: Falling time; Rs1090: Rise slope 10%-90%; WinR: Wash-in rate; Fs50: Falling slope 50%; AUC: Area under the curve; TTP: Time to peak; mTT: Mean transit time; WoutR: Wash-out rate.

Citation: Yang ZY, Wan WN, Zhao L, Li SN, Liu Z, Sang L. Noninvasive prediction of Ki-67 expression in pancreatic cancer via contrast-enhanced ultrasound quantitative parameters: A diagnostic model study. World J Gastrointest Oncol 2025; 17(6): 107919
URL: https://www.wjgnet.com/1948-5204/full/v17/i6/107919.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i6.107919