Noninvasive prediction of Ki-67 expression in pancreatic cancer via contrast-enhanced ultrasound quantitative parameters: A diagnostic model study

doi:10.4251/wjgo.v17.i6.107919

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Jun 15, 2025; 17(6): 107919
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.107919

Table 3 Contrast-enhanced ultrasound parameters in different Ki-67 expression groups, median (interquartile range)

	Ki-67 < 50%	Ki-67 ≥ 50%	U value	P value
Rs50	6.84 (5.23 to 10.55)	11.35 (9.56 to 15.10)	144.500	< 0.001^b
IMAX	46.37 (37.60 to 57.56)	74.12 (61.80 to 89.20)	102.000	< 0.001^b
RT	14.42 (10.97 to 15.30)	11.45 (9.35 to 12.32)	220.000	0.013^a
WinAUC	296.42 (162.34 to 550.78)	453.86 (178.36 to 1302.49)	278.000	0.143
FHT	32.58 (26.86 to 41.07)	30.70 (25.30 to 36.00)	311.500	0.376
WoutAUC	19911.74 (12434.98 to 27114.02)	30764.31 (22543.16 to 42157.32)	202.000	0.005^b
WioAUC	20609.49 (13213.08 to 27290.88)	31196.99 (22668.28 to 42665.07)	202.000	0.005^b
WoutR	19911.74 (195.31 to 354.02)	383.07 (331.66 to 696.14)	132.000	< 0.001^b
FT	73.82 (62.50 to 99.51)	71.36 (57.58 to 87.80)	305.000	0.319
Rs1090	4.57 (3.79 to 6.76)	10.47 (8.76 to 11.82)	99.000	< 0.001^b
WinR	25.33 (17.77 to 51.06)	37.99 (18.41 to 134.44)	275.500	0.131
Fs50	-0.52 (-0.68 to 0.38)	-0.92 (-1.16 to 0.76)	117.500	< 0.001^b
AUC	25841.89 (18120.31 to 37170.46)	39426.38 (31969.68 to 59121.85)	198.00	0.004^b
TTP	15.31 (11.28 to 17.36)	11.74 (10.30 to 13.10)	226.500	0.018^a
mTT	68.89 (54.54 to 91.66)	76.38 (48.34 to 94.23)	356.000	0.910

^aP < 0.05.

^bP < 0.01.

Rs50: Rise slope 50%; IMAX: Maximum intensity; RT: Rise time; WinAUC: Wash-in area under the curve; FHT: Falling half time; WoutAUC: Wash-out area under the curve; WioAUC: Wash-in and out area under curve; FT: Falling time; Rs1090: Rise slope 10%-90%; WinR: Wash-in rate; Fs50: Falling slope 50%; AUC: Area under the curve; TTP: Time to peak; mTT: Mean transit time; WoutR: Wash-out rate.

Citation: Yang ZY, Wan WN, Zhao L, Li SN, Liu Z, Sang L. Noninvasive prediction of Ki-67 expression in pancreatic cancer via contrast-enhanced ultrasound quantitative parameters: A diagnostic model study. World J Gastrointest Oncol 2025; 17(6): 107919
URL: https://www.wjgnet.com/1948-5204/full/v17/i6/107919.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i6.107919