Prognostic value of hemoglobin-to-red cell distribution width ratio and inflammation markers in colorectal cancer

Table 2 Cox regression analysis for overall survival values

Variable	Category	Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Patients’ characteristics
Sex	Male/female	0.66 (0.44-0.99)	0.0451
ECOG PS	< 2/≥ 2	1.25 (0.84-1.87)	0.270
Body mass index	< 25/≥ 25	1.42 (0.95-2.13)	0.084
Age	< 65/≥ 65	1.51 (1.02-2.25)	0.0401	1.59 (1.06-2.39)	0.0251
Tumor grade	< 2/≥ 2	0.97 (0.56-1.65)	0.897
Tumor location	Right/left	1.51 (0.87-2.63)	0.142
Metastasis status	De novo/recurrence	1.09 (0.72-1.66)	0.693
Liver metastasis	No/yes	0.99 (0.64-1.54)	0.976
Peritoneal metastasis	No/yes	1.32 (0.81-2.15)	0.273
Lung metastasis	No/yes	0.90 (0.60-1.35)	0.607
Metastasectomy	No/yes	0.42 (0.24-0.71)	0.0011	0.49 (0.29-0.85)	0.0111
Treatment lines	< 3/≥ 3	0.86 (0.70-1.07)	0.168
Laboratory parameters
CEA (ng/dL)	< 6.1/≥ 6.1	1.70 (1.14-2.55)	0.0101	1.51 (1.00-2.28)	0.0481
CA19-9 (U/mL)	< 21.6/≥ 21.6	1.34 (0.91-1.98)	0.138
NLR	< 3.09/≥ 3.09	1.38 (0.93-2.04)	0.108
PLR	< 177.5/≥ 177.5	1.57 (1.06-2.33)	0.0241	1.63 (1.09-2.44)	0.0181
SII	< 835.96/≥ 835.96	1.67 (1.13-2.46)	0.0101
MLR	< 0.38/≥ 0.38	1.00 (0.67-1.48)	0.988
HRR	< 0.83/≥ 0.83	0.64 (0.43-0.95)	0.0251
PRR	< 18.85/≥ 18.85	1.19 (0.80-1.77)	0.384
PDWLR	< 10.87/≥ 10.87	1.05 (0.71-1.57)	0.794

¹Significant values. ECOG PS: Eastern Cooperative Oncology Group-performance score; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SII: Systemic immune-inflammation index; MLR: Monocyte-to-lymphocyte ratio; HRR: Hemoglobin-to-red cell distribution width ratio; PRR: Platelet-to-red cell distribution width ratio; PDWLR: Platelet distribution width to lymphocyte ratio; HR: Hazard ratio; CI: Confidence interval.