Analysis of serum S100A12, soluble advanced glycation end products receptor, and gut microbiome in elderly patients with colorectal cancer

Figure 4 Receiver operating characteristic curve for the predictive diagnostic value of pre-chemotherapy serum S100 calcium-binding protein A12 and soluble receptor for advanced glycation end products levels for chemotherapy ineffectiveness in colorectal cancer. The receiver operating characteristic curve highlighted the superior predictive accuracy of the combined S100 calcium-binding protein A12/soluble receptor for advanced glycation end products model (green line) compared to individual biomarkers. The diagonal reference line (dashed line) represents random chance (area under the curve = 0.5). S100A12: S100 calcium-binding protein A12; sRAGE: Soluble receptor for advanced glycation end products.