Analysis of serum S100A12, soluble advanced glycation end products receptor, and gut microbiome in elderly patients with colorectal cancer

Table 3 Predictive diagnostic value of pre-chemotherapy serum S100 calcium-binding protein A12 and soluble receptor for advanced glycation end products levels for chemotherapy ineffectiveness in colorectal cancer

Indicator	Optimal cutoff value	AUC	95%CI	P value	Sensitivity (%)	Specificity (%)
S100A12	324.89 μg/L	0.802	0.713-0.864	< 0.05	79.04	82.03
sRAGE	435.76 ng/L	0.841	0.776-0.915	< 0.05	81.43	75.32
Combined	-	0.914	0.843-0.962	< 0.05	86.07	88.89

AUC: Area under the curve; CI: Confidence interval; S100A12: S100 calcium-binding protein A12; sRAGE: Soluble receptor for advanced glycation end products.