Analysis of serum S100A12, soluble advanced glycation end products receptor, and gut microbiome in elderly patients with colorectal cancer

Table 1 Comparison of serum S100 calcium-binding protein A12 and soluble receptor for advanced glycation end products levels before chemotherapy in patients with colorectal cancer with different gut microbiota conditions

Group	S100A12 (μg/L)	sRAGE (ng/L)
Normal microbiota (n = 50)	265.37 ± 45.74	381.56 ± 36.78
Mild dysbiosis (n = 43)	302.53 ± 56.97b,1	441.38 ± 48.73b,1
Severe dysbiosis (n = 27)	340.26 ± 52.39a,b,1,2	525.64 ± 37.32a,b,1,2
F value	19.162	105.972
P value	< 0.001	< 0.001

^aP < 0.05.

^bP < 0.01.

¹P vs normal group.

²P vs mild dysbiosis group.

S100A12: S100 calcium-binding protein A12; sRAGE: Soluble receptor for advanced glycation end products.