Tumor-derived exosomal miR-425-5p and miR-135b-3p enhance colorectal cancer progression through immune suppression and vascular permeability promotion

Figure 4 Inhibition of exosomal miR-425-5p and mir-135b-3p reduces tumor growth, metastasis, and angiogenesis in vivo. A: Body weight, tumor volume, tumor weight and gross size of tumors from mice treated with HCT116 cells; B: Number of liver and lung tumors; C: Representative images of hematoxylin and eosin staining in tumor tissues; D: Immunohistochemical staining of CD34 in tumor tissues. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs model (n = 3 per group). CD34: Hematopoietic progenitor cell antigen CD34.