Diagnostic value of serum pepsinogen, gastrin, and carbohydrate antigens in gastric ulcer and gastric cancer

Table 3 Diagnostic value of pepsinogen, gastrin-17, carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4 for gastric ulcer and cancer

	Cut-off value	GC (n = 71)	GU (n = 88)	χ2	P value	Sensitivity	Specificity	Youden index	Positive predictive value	Negative predictive value
PGI, ng/mL	≥ 169.855	21	22	0.417	0.518	0.296	0.75	0.046	0.488	0.569
	< 169.855	50	66
PGII, ng/mL	≥ 30.555	22	5	17.848	< 0.001	0.31	0.943	0.253	0.815	0.629
	< 30.555	49	83
PGI/PGII ratio	≥ 16.529	11	12	0.109	0.741	0.155	0.864	0.019	0.478	0.559
	< 16.529	60	76
G17, pmol/L	≥ 6.435	47	34	11.944	0.001	0.662	0.614	0.276	0.58	0.692
	< 6.435	24	54
CEA, ng/mL	≥ 2.005	36	15	20.433	< 0.001	0.507	0.83	0.337	0.706	0.676
	< 2.005	35	73
CA19-9, U/mL	≥ 16.65	23	7	15.333	< 0.001	0.324	0.92	0.244	0.767	0.628
	< 16.65	48	81
CA72-4, U/mL	≥ 2.075	44	18	28.473	< 0.001	0.62	0.795	0.415	0.71	0.722
	< 2.075	27	70

PG: Pepsinogen; G17: Gastrin-17; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; GU: Gastric ulcer; GC: Gastric cancer; CG: Chronic non-atrophic gastritis.