Diagnostic value of serum pepsinogen, gastrin, and carbohydrate antigens in gastric ulcer and gastric cancer

doi:10.4251/wjgo.v17.i6.105931

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jun 15, 2025; 17(6): 105931
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.105931

Table 2 Differences in pepsinogen, gastrin-17, carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4 in different disease states, M (Q₂₅, Q₇₅)

	GC (n = 71)	GU (n = 88)	CG (n = 104)	P value
PGI, ng/mL	85.71 (48.19, 176.47)^a	121.37 (75.42, 170.03)	96.07 (73.44, 139.51)	0.025
PGII, ng/mL	18.87 (9.57, 35.14)^b	15.16 (10.19, 21.58)^c	8.73 (5.23, 12.66)	< 0.001
PGI/PGII ratio	5.02 (2.80, 8.13)^a^,^b	8.06 (6.18, 9.67)^c	12.88 (8.99, 17.58)	< 0.001
G17, pmol/L	8.60 (3.97, 19.82)^a^,^b	4.96 (2.41, 9.10)^c	2.80 (1.33, 5.83)	< 0.001
CEA, ng/mL	2.02 (1.00, 6.54)^a^,^b	0.91 (0.51, 1.77)	1.13 (0.80, 1.55)	< 0.001
CA19-9, U/mL	7.61 (3.75, 22.13)^a	4.96 (3.50, 8.93)	5.36 (3.50, 10.96)	0.019
CA72-4, U/mL	2.89 (1.19, 11.74)^a^,^b	0.65 (0.60, 1.74)	0.81 (0.60, 1.67)	< 0.001

^aP < 0.05 vs gastric ulcer group.

^bP < 0.05 vs chronic non-atrophic gastritis (CG) group.

^cP < 0.05 vs CG group.

PG: Pepsinogen; G17: Gastrin-17; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; GU: Gastric ulcer; GC: Gastric cancer; CG: Chronic non-atrophic gastritis.

Citation: Xu J, Li SX, Liu D, Chen LX, Chen X. Diagnostic value of serum pepsinogen, gastrin, and carbohydrate antigens in gastric ulcer and gastric cancer. World J Gastrointest Oncol 2025; 17(6): 105931
URL: https://www.wjgnet.com/1948-5204/full/v17/i6/105931.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i6.105931