Endothelial Per-Arnt-Sim domain-containing protein 1 expression is correlated with poor prognosis and promotes invasion and metastasis in gastric cancer

Table 2 Univariate and multivariate Cox regression analysis results

Characteristics	Univariate analysis		Multivariate analysis
	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Age	1.009 (0.962-1.059)	0.703
Gender	1.636 (0.582-4.599)	0.351
BMI	0.882 (0.707-1.100)	0.265
H. pylori infection	1.069 (0.301-3.788)	0.918
Hypertension	1.504 (0.514-4.402)	0.456
Diabetes	1.785 (0.567-5.622)	0.322
Coronary heart disease	1.831 (0.652-5.147)	0.251
Tumor location	1.391 (0.700-2.764)	0.346
Vascular invasion	15.876 (5.324-47.336)	0.001	2.056 (0.363-11.649)	0.415
T stage (T1+T2 vs T3+T4)	3.929 (2.230-6.923)	0.001	1.390 (0.594-3.250)	0.448
N stage (N0 vs N1+N2+N3)	3.005 (1.909-4.729)	0.001	0.811 (0.308-2.134)	0.671
M stage (M0 vs M1)	11.511 (4.053-32.695)	0.001	0.467 (0.055-3.970)	0.486
TNM stage (I+II vs III+IV)	3.069 (1.995-4.721)	0.001	3.686 (0.721-18. 840)	0.117
Histological type	1.529 (0.935-2.499)	0.091
The degree of differentiation	0.733 (0.250-2.144)	0.570
Operation method	6.773 (2.192-9. 336)	0.007	1.670 (0.102-17.243)	0.719
Hospital stay time	1.279 (1.084-1.508)	0.004	0.996 (0.782-1.268)	0.973
EPAS1	2.193 (1.191-4.039)	0.012	2.095 (1.019-4.307)	0.044

BMI: Body mass index; H. pylori: Helicobacter pylori.