Endothelial Per-Arnt-Sim domain-containing protein 1 expression is correlated with poor prognosis and promotes invasion and metastasis in gastric cancer

Table 1 Relationship between endothelial Per-Arnt-Sim domain-containing protein 1 and clinicopathological features of gastric cancer patients in the clinic, n (%)

Characteristics	High EPAS1 (n = 58)	Low EPAS1 (n = 37)	χ2/t	P value
Age (years)	64.39 ± 11.89	61.84 ± 10.66	1.064	0.290
Gender (male/female)	41/14	26/11	0.002	0.965
BMI (kg/m2)	23.51 ± 2.47	24.21 ± 2.60	1.309	0.194
H. pylori infection	12 (20.69)	6 (16.21)	0.294	0.587
Hypertension	12 (20.69)	10 (27.03)	0.510	0.475
Diabetes	9 (15.52)	8 (21.62)	0.573	0.449
Coronary heart disease	16 (27.59)	11 (29.73)	0.051	0.821
Tumor location			0.426	0.808
Cardia bottom of stomach	27 (46.55)	18 (48.65)
Body of stomach	22 (37.93)	15 (40.54)
Pyloric department	9 (15.52)	4 (10.81)
Vascular invasion	12 (20.69)	5 (13.51)	0.792	0.374
T stage			9. 631	0.022
T1	22 (37.93)	25 (67.57)
T2	18 (31.03)	8 (21.62)
T3	13 (22.42)	4 (10.81)
T4	5 (8.62)	0 (0.00)
N stage			2.020	0.568
N0	33 (56.90)	26 (70.27)
N1	14 (24.14)	7 (18.92)
N2	7 (12.07)	3 (8. 11)
N3	4 (6.89)	1 (2.70)
M stage			0.743	0.389
M0	48 (82.76)	33 (89.19)
M1	10 (17.24)	4 (10.81)
TNM stage			3.451	0.327
I	32 (55.17)	26 (70.27)
II	11 (18.97)	6 (16.21)
III	7 (12.07)	1 (2.70)
IV	8 (13.79)	4 (10.81)
Histological type			2.587	0.629
Papillary adenocarcinoma	11 (18.97)	9 (24.32)
Tubular adenocarcinoma	25 (43.10)	14 (37.84)
Mucous adenocarcinoma	13 (22.42)	7 (18.92)
Signet ring cell	7 (12.07)	7 (18.92)
Anaplastic	2 (3.45)	0 (0.00)
The degree of differentiation			4.250	0.039
Poorly differentiated	28 (48.28)	10 (27.03)
Medium to high differentiation	30 (51.72)	27 (72.97)
Operation method			2.657	0.103
ESD	23 (39.66)	21 (56.76)
Gastrectomy	35 (60.34)	16 (43.24)
Hospital stay time (d)	11.57 ± 2.84	9. 54 ± 2.40	3.599	< 0.05
OS (m)	23.62 ± 4.86	30.68 ± 4.40	7.149	< 0.05
Mortality rate	12 (20.69)	3 (8.11)	2.689	0.101

BMI: Body mass index; OS: Overall survival; ESD: Endoscopic submucosal dissection; H. pylori: Helicobacter pylori.