Identification and validation of extracellular matrix-related genes in the progression of gastric cancer with intestinal metaplasia

Figure 7 Prognostic model validation and hub gene analysis. A: Prognosis model in the GSE15459 dataset risk score Kaplan-Meier curve; B: Prognostic model in the GSE15459 dataset risk factor map; C: The time-varying prognostic receiver operating characteristic curve of the prognostic model in the GSE15459 dataset; D: TNFRSF11B COL1A1, COL3A1, SERPINE1, secreted protein acidic and rich in cysteine (SPARC), PDGFRB in diagnosis of least absolute shrinkage and selection operator GSE191275 dataset regression coefficient; E: Two variables with non-zero regression coefficients generated by the least absolute shrinkage and selection operator analysis in GSE191275: SPARC/TNFRSF11B; F and G: SPARC expression in The Cancer Genome Atlas (TCGA)-stomach adenocarcinoma (STAD) unpaired samples and paired samples; H: Expression of SPARC in normal gastric mucosa and intestinal metaplasia samples of GSE191275; I and J: SPARC was expressed in TCGA-STAD dataset at different clinical stages; K: Low and high SPARC expression groups had obviously different survivals in TCGA-STAD, clinical stage IV, T3T4 and N2N3 (P < 0.05); L: Radar map of SPARC expression in pancarcinoma; M: Prognosis and overall survival of SPARC in pancarcinoma. ^aP < 0.001. HR: Hazard ratio; TPR: True positive rate; FPR: False positive rate; TPM: Transcripts per million; AUC: Area under the curve; ACC: Adrenocortical carcinoma; BLCA: Bladder urothelial carcinoma; BRCA: Breast invasive carcinoma; CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL: Cholangiocarcinoma; COAD: Colon adenocarcinoma; DLBC: Lymphoid neoplasm diffuse large B-cell lymphoma; ESCA: Esophageal carcinoma; GBM: Glioblastoma multiforme; HNSC: Head and neck squamous cell carcinoma; KICH: Kidney chromophobe; KIRC: Kidney renal clear cell carcinoma; KIRP: Kidney renal papillary cell carcinoma; LAML: Acute myeloid leukemia; LGG: Brain lower grade glioma; LIHC: Liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; LUSC: Lung squamous cell carcinoma; MESO: Mesothelioma; OV: Ovarian serous cystadenocarcinoma; PAAD: Pancreatic adenocarcinoma; PRAD: Prostate adenocarcinoma; PCPG: Pheochromocytoma and paraganglioma; READ: Rectum adenocarcinoma; SARC: Sarcoma; SKCM: Skin cutaneous melanoma; STAD: Stomach adenocarcinoma; TGCT: Testicular germ cell tumors; THCA: Thyroid carcinoma; THYM: Thymoma; UCS: Uterine carcinosarcoma; UVM: Uveal melanoma; UCEC: Uterine corpus endometrial carcinoma; SPARC: Secreted protein acidic and rich in cysteine.