Identification and validation of extracellular matrix-related genes in the progression of gastric cancer with intestinal metaplasia

Figure 2 The Cancer Genome Atlas-stomach adenocarcinoma volcano plot and intersection gene analysis. A: Volcano plot for differentially expressed genes (DEGs) between normal and gastric cancer in The Cancer Genome Atlas-stomach adenocarcinoma (STAD); B and C: Venn diagram of the intersection of hub genes in intestinal metaplasia with DEGs in STAD; D and E: Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results of upregulated DEGs; F and G: Downregulated DEGs; H: The Venn diagram of the intersection of hub genes in intestinal metaplasia, upregulated DEGs in STAD, and genes related to the extracellular matrix; I: A heatmap of the expression of 18 intersecting genes in GSE191275; J: A heatmap of the expression of 18 intersecting genes in The Cancer Genome Atlas-STAD. DEGs: Differentially expressed genes; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; ECM: Extracellular matrix.