Kinesin family member 14 in digestive tract malignancies: Oncogenic mechanisms, clinical implications, and therapeutic prospects

Figure 1 Mechanism of action of Kinesin family member 14 in esophageal, gastric, liver, and colorectal cancer. ESCC: Esophageal squamous cell carcinoma; GC: Gastric cancer; HCC: Hepatocellular carcinoma; CRC: Colorectal cancer; KIF14: Kinesin family member 14; miR-154-5p: MicroRNA-154-5p; miR-200C: MicroRNA-200C; LETM1: Leucine zipper-EF-hand containing transmembrane protein 1; SOX17: SRY-Box 17; RFC3: Replication factor C subunit 3; PI3K/AKT: Phosphoinositol-3-kinase/protein kinase B; Bax: BCL2-associated X protein; p27KIP1: Cyclin-dependent kinase inhibitor 1B; VEGF: Vascular endothelial growth factor; VEGFA: Vascular endothelial growth factor A; VEGFR1: Vascular endothelial growth factor receptor 1; VEGFR2: Vascular endothelial growth factor receptor 2; solid arrow (→): Indicates activation or promotion; T-bar arrow (⊣): Indicates inhibition.