Role and mechanism of sarcosine dehydrogenase in the progression of gallbladder cancer through chemokine pathways

Figure 6 Synergistic effects of sarcosine dehydrogenase and C-X-C motif chemokine ligand 1 regulation on the function of gallbladder cancer cells. A: Gallbladder cancer cell proliferation was detected after sarcosine dehydrogenase (SARDH) overexpression and C-X-C motif chemokine ligand 1 (CXCL1) silencing; B: Gallbladder cancer cell migration and invasion were detected after SARDH overexpression and CXCL1 silencing; C: Gallbladder cancer cell proliferation was detected after simultaneous overexpression of SARDH and CXCL1; D: Gallbladder cancer cell proliferation was detected after overexpression of both SARDH and CXCL1; E: Western blot analysis showed that interference with the SARDH/CXCL1 axis inhibited the activation of protein kinase B and extracellular signal-regulated kinase (ERK)1/ERK2 signaling pathways in BGC-SD. CXCL1: C-X-C motif chemokine ligand 1; SARDH: Sarcosine dehydrogenase; Akt: Protein kinase B; ERK: Extracellular signal-regulated kinase.