Role and mechanism of sarcosine dehydrogenase in the progression of gallbladder cancer through chemokine pathways

doi:10.4251/wjgo.v17.i6.105016

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Jun 15, 2025 (publication date) through Jul 28, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jun 15, 2025; 17(6): 105016
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.105016

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Figure 3 Effects of sarcosine dehydrogenase on the migration, invasion, adhesion, and apoptosis of gallbladder cancer cells. A: Sarcosine dehydrogenase (SARDH) overexpression inhibited the migration and invasion of gallbladder cancer cells; B: SARDH silencing promoted the migration and invasion of gallbladder cancer cells; C: SARDH overexpression inhibited the adhesion of gallbladder cancer cells; D: SARDH silencing promoted cell adhesion of gallbladder cancer cells; E: Flow cytometry analysis showed that SARDH overexpression promoted the apoptosis of gallbladder cancer cells; F: Flow detection of SARDH silencing inhibited the apoptosis of gallbladder carcinoma cells. SARDH: Sarcosine dehydrogenase.

Citation: Gao Z, Zhang X, He H. Role and mechanism of sarcosine dehydrogenase in the progression of gallbladder cancer through chemokine pathways. World J Gastrointest Oncol 2025; 17(6): 105016
URL: https://www.wjgnet.com/1948-5204/full/v17/i6/105016.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i6.105016