Nomogram-based prognostic stratification for resectable gastric signet-ring cell carcinoma and adenocarcinoma: A retrospective cohort study

Table 2 Univariate and multivariate analysis of overall survival after propensity score matching

Variable	Univariate analyses			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Subtype
GA	Ref.			Ref.
GSRCC	1.601	0.973-2.635	0.064	1.112	0.916-1.349	0.282
Age (year)
< 60	Ref.			Ref.
≥ 60	1.391	1.148-1.685	0.001	1.330	1.094-1.617	0.004
Gender
Male	Ref.
Female	0.94	0.764-1.156	0.556
BMI (kg/m2)
< 24	Ref.
≥ 24	0.715	0.733-1.078	0.232
Smoking history
Yes	Ref.
No	0.938	0.733-1.137	0.514
Drinking history
Yes	Ref.
No	1.039	0.856-1.261	0.698
Tumor location
Upper	Ref.
Middle	0.559	0.427-0.732	< 0.001
Lower	0.585	0.464-0.737	< 0.001
More than two position or total	1.964	1.363-2.83	< 0.001
Poor differentiation
Yes	Ref.			Ref.
No	0.628	0.482-0.818	0.001	0.766	0.584-0.999	0.049
Size (cm)
< 4	Ref.			Ref.
≥ 4	2.714	2.172-3.390	< 0.001	1.376	1.088-1.739	0.008
Perineural invasion
Yes	Ref.
No	0.441	0.358-0.542	< 0.001
Vascular invasion
Yes	Ref.			Ref.
No	0.402	0.330-0.489	< 0.001	0.744	0.606-0.915	0.005
pTNM stage
I	Ref.		< 0.001	Ref.
II	2.805	1.701-4.628		2.498	1.499-4.164	< 0.001
III	10.631	6.97-16.215		8.004	5.065-12.648	< 0.001
Adjuvant chemotherapy
Yes	Ref.			Ref.
No	1.169	1.022-1.338	0.023	1.123	0.922-1.368	0.250

BMI: Body mass index; GA: Gastric adenocarcinoma; GSRCC: Gastric signet ring cell carcinoma; pTNM: Post-treatment nodal margin; HR: Hazard ratio; CI: Confidence interval.