Significance of serum APE1-AAbs, PTX-3, and miR-486-3p in patients with colorectal cancer undergoing radical surgery

Table 6 Predictive value of apurinic/apyrimidinic endonuclease 1 autoantibodies, peripheral pentraxin-3, and miR-486-3p levels alone and their combination for postoperative recurrence and metastasis of colorectal cancer

Indicator	Optimal cut-off value	AUC	95%CI	P value	Sensitivity, %	Specificity, %
APE1-AAbs	7.84 ng/mL	0.764	0.653-0.849	< 0.05	79.65	71.39
PTX-3	8.83 ng/mL	0.783	0.685-0.872	< 0.05	78.72	70.27
MiR-486-3p	8.49	0.806	0.709-0.891	< 0.05	85.69	72.51
Combination		0.875	0.782-0.943	< 0.05	92.84	90.35

AUC: Areas under the curve; CI: Confidence interval; APE1-AAbs: Apurinic/apyrimidinic endonuclease 1 autoantibodies; PTX-3: Peripheral pentraxin-3.