SPDL1 inhibition enhances colorectal cancer progression via epidermal growth factor receptor/extracellular signal-regulated kinase pathways

doi:10.4251/wjgo.v17.i5.104686

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May 15, 2025 (publication date) through Jun 9, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. May 15, 2025; 17(5): 104686
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104686

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Figure 7 Proposed pathway by which reduced SPDL1 expression leads to epithelial-mesenchymal transition and promotes cell migration and invasion in colorectal cancer. EGF: Epidermal growth factor; EGFR: Epidermal growth factor receptor; MEK: Mitogen-activated protein kinase; ERK: Extracellular signal-regulated kinase; EMT: Epithelial-mesenchymal transition.

Citation: Peng P, Sun J, Li MS, Cheng RX, Liu SQ, Qin MB, Zhang JX, Huang JA. SPDL1 inhibition enhances colorectal cancer progression via epidermal growth factor receptor/extracellular signal-regulated kinase pathways. World J Gastrointest Oncol 2025; 17(5): 104686
URL: https://www.wjgnet.com/1948-5204/full/v17/i5/104686.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i5.104686