SPDL1 inhibition enhances colorectal cancer progression via epidermal growth factor receptor/extracellular signal-regulated kinase pathways

Figure 4 Transcriptomics analysis. A: Differential gene expression volcano map; B-D: Gene Ontology enrichment analysis; E: Kyoto Encyclopedia of Genes and Genomes enrichment analyses; F: Average expression of epidermal growth factor receptor; G: Average expression of protein kinase A; H: Mitogen-activated protein kinase signaling pathway-heatmap; I: Cell cycle signaling pathway-heatmap. ^aP < 0.05. si-SPDL1: Small interfering RNA targeting SPDL1; DEGS: Differentially expressed genes; GO: Gene Ontology; MCM: Minichromosome maintenance complex; CHOP: C/EBP homologous protein; ATP: Adenosine triphosphate; KEGG: Kyoto Encyclopedia of Genes and Genomes; MAPK: Mitogen-activated protein kinase; EGFR: Epidermal growth factor receptor; PKA: Protein kinase A; TPM: Transcripts per million.