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©The Author(s) 2025.
World J Gastrointest Oncol. May 15, 2025; 17(5): 104686
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104686
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104686
Figure 4 Transcriptomics analysis.
A: Differential gene expression volcano map; B-D: Gene Ontology enrichment analysis; E: Kyoto Encyclopedia of Genes and Genomes enrichment analyses; F: Average expression of epidermal growth factor receptor; G: Average expression of protein kinase A; H: Mitogen-activated protein kinase signaling pathway-heatmap; I: Cell cycle signaling pathway-heatmap. aP < 0.05. si-SPDL1: Small interfering RNA targeting SPDL1; DEGS: Differentially expressed genes; GO: Gene Ontology; MCM: Minichromosome maintenance complex; CHOP: C/EBP homologous protein; ATP: Adenosine triphosphate; KEGG: Kyoto Encyclopedia of Genes and Genomes; MAPK: Mitogen-activated protein kinase; EGFR: Epidermal growth factor receptor; PKA: Protein kinase A; TPM: Transcripts per million.
- Citation: Peng P, Sun J, Li MS, Cheng RX, Liu SQ, Qin MB, Zhang JX, Huang JA. SPDL1 inhibition enhances colorectal cancer progression via epidermal growth factor receptor/extracellular signal-regulated kinase pathways. World J Gastrointest Oncol 2025; 17(5): 104686
- URL: https://www.wjgnet.com/1948-5204/full/v17/i5/104686.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v17.i5.104686