Switching from messenger RNAs to noncoding RNAs, METTL3 is a novel colorectal cancer diagnosis and treatment target

doi:10.4251/wjgo.v17.i5.104076

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May 15, 2025 (publication date) through Aug 12, 2025

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. May 15, 2025; 17(5): 104076
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104076

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Figure 1 Dynamic regulation of N6-methyladenosine modification. N6-methyladenosine (m6A) writers, erasers, and readers control the process of m6A modification. Writers (METTL3, METTL14, WTAP, METTL5, and METTL16) catalyze m6A deposition, erasers (FTO and ALKBH5) remove methyl groups, and readers (YTHDF1/YTHDF2/YTHDF3, YTHDC1/YTHDC2/YTHDC3, IGF2BP1/IGF2BP2/IGF2BP3) decode these marks to influence RNA stability, messenger RNA translation, RNA degradation, translocation, RNA splicing, structure switching, and primary microRNA processing. M6A: N6-methyladenosine.

Citation: Liao JN, Ni WJ, Wu PH, Yang YD, Yang Y, Long W, Xie MZ, Zhu XZ, Xie FH, Leng XM. Switching from messenger RNAs to noncoding RNAs, METTL3 is a novel colorectal cancer diagnosis and treatment target. World J Gastrointest Oncol 2025; 17(5): 104076
URL: https://www.wjgnet.com/1948-5204/full/v17/i5/104076.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i5.104076