Switching from messenger RNAs to noncoding RNAs, METTL3 is a novel colorectal cancer diagnosis and treatment target

doi:10.4251/wjgo.v17.i5.104076

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May 15, 2025 (publication date) through Jun 11, 2025

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. May 15, 2025; 17(5): 104076
Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104076

Table 2 Summary of N6-methyladenosine modification of noncoding RNAs in colorectal cancer

METTL3 expression	M6A modified ncRNAs	Function of METTL3	Ref.
Upregulation	SNHG1	Cell proliferation	Xu et al[84]
Upregulation	FAM83H-AS1	Cell proliferation	Luo et al[85]
Upregulation	pri-miRNA-1246	Cell invasion and migration	Peng et al[78]
Upregulation	circ1662	Cell invasion and migration	Chen et al[86]
Upregulation	POU6F2-AS1	Metabolism	Jiang et al[87]
Upregulation	miR-181b-5p	Drug resistance	Pan et al[88]
Upregulation	Circ0124554	Drug resistance	Zhong et al[89]

pri-miRNA: Primary miRNA; ncRNAs: Noncoding RNAs; m6A: N6-methyladenosine.

Citation: Liao JN, Ni WJ, Wu PH, Yang YD, Yang Y, Long W, Xie MZ, Zhu XZ, Xie FH, Leng XM. Switching from messenger RNAs to noncoding RNAs, METTL3 is a novel colorectal cancer diagnosis and treatment target. World J Gastrointest Oncol 2025; 17(5): 104076
URL: https://www.wjgnet.com/1948-5204/full/v17/i5/104076.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i5.104076