Switching from messenger RNAs to noncoding RNAs, METTL3 is a novel colorectal cancer diagnosis and treatment target

Table 1 Summary of N6-methyladenosine modification of messenger RNAs in colorectal cancer

METTL3 expression	M6A modified mRNAs	Function of METTL3	Ref.
Upregulation	CCN1	Cell proliferation	Zhu et al[61]
Upregulation	YPEL5	Cell proliferation	Zhou et al[62]
Upregulation	PTTG3P	Cell proliferation	Zheng et al[63]
Upregulation	KIF26B	Cell invasion and migration	Chen et al[64]
Downregulation	P38/ERK	Cell invasion and migration	Deng et al[65]
Upregulation	HK2 and GLUT1	Metabolism	Shen et al[45]
Upregulation	GLUT1	Metabolism	Chen et al[66]
Upregulation	REG1α	Metabolism	Zhou et al[67]
Upregulation	P53R273H	Drug resistance	Uddin et al[68]
Upregulation	RAD51AP1	Drug resistance	Li et al[69]
Upregulation	TRAF5	Drug resistance	Lan et al[70]
Upregulation	LDHA	Drug resistance	Zhang et al[71]

ERK: Extracellular regulated protein kinases; HK2: Hexokinase 2; GLUT1: Glucose transporter type 1; mRNAs: Messenger RNAs; m6A: N6-methyladenosine.